MEG3 and neoplasm: To assess the relationship between the MEG3 secondary structure and the function of this lncRNA as a tumor suppressor, we performed cell cycle (Lu et al., 2013) and luciferase reporter assays (Zhang et al., 2010a) in HCT116, a human cell line that expresses wild-type p53 and negligible levels of endogenous MEG3 (Figure S5N).