There was only one “likely neutral” variant (GRCh37, chr4:153249393-153249393 G>T) predicted as potential clinical significant by VIC, because it was present in the therapeutic (PMKB) and somatic database (pathogenic in COSMIC), and the affected gene FBXW7 was involved in cancer-related pathway, and five computational tools predicted it as deleterious. The gene discussed is FBXW7; the disease is cancer.