However, analyzing the mRNA levels of MDM2, EWSR1, CDKN2A, and HMGA2 in dedifferentiated LPS, MDM2 and CDKN2A in LMS, and EWSR1 in UPS revealed that MDM2 and EWSR1 were upregulated in dedifferentiated LPS, while HMGA2 was downregulated in dedifferentiated LPS, and EWSR1 was upregulated in UPS, but none of them showed any prognostic value in the three histologic STS subtypes (Figs. 3 and 4). The gene discussed is HMGA2; the disease is telomere syndrome.