The majority (> 70%) of patients had positive q6 (+q6) values showing the predicted expression of q6 biomarkers from our HNSCC cell line data, with PLAU, FN1 and CDCA5 being upregulated and CRNN, CLEC3B and DUOX1 downregulated. Here, DUOX1 is linked to head and neck squamous cell carcinoma.