Yadav et al. [51] used mutated DPAGT1, REPS1, and ADPGK to prepare peptide vaccines that can delay the growth of tumor cells in mouse models; at the same time, they observed that neoantigen-specific T cells expressed high levels of PD-1 and TIM3 receptors, which acted as negative regulators of immune response, and even induced apoptosis of T cells, suggesting that T cells become dysfunctional during this process [107]. This evidence concerns the gene PDCD1 and neoplasm.