Whether mutations can form tumor neoantigens depends on several factors: 1) whether the mutated sequence can be translated into protein; 2) whether the mutated protein can be processed into peptides and presented; 3) affinity between the mutated peptide and MHC molecules of the patients; 4) affinity of mutant peptide-MHC complex with T cell receptor (TCR) [47]. The gene discussed is HLA-C; the disease is neoplasm.