In addition to identifying a methylation-specific signature for ADEH+, a goal of the current study was to determine whether an easily accessible tissue such as whole blood can be the source of a biomarker which might facilitate the early diagnosis of patients with AD prone to disseminated viral infections, and whether or not methylation changes in the blood can distinguish between ADEH+ and ADEH−. This evidence concerns the gene ADSS2 and Alzheimer disease.