Using a set of 129 CpGs that belong to AD candidate genes of interest (FLG [5, 17, 18, 25, 29, 40], LCE1B [40, 41], RPTN [41, 42], IL4, IL13 [18, 30, 33–35, 40] and its receptors, IFNs [6, 7, 10] and TSLP [13, 14, 18, 30, 40], see Additional file 1 Table S10), we identified CpGs significant by phenotype in the discovery and suggestive in the replication data sets in the IL13 and IL4 genes (Fig. 2, Table 2). Here, LCE1B is linked to Alzheimer disease.