RPTN and Alzheimer disease: Using a set of 129 CpGs that belong to AD candidate genes of interest (FLG [5, 17, 18, 25, 29, 40], LCE1B [40, 41], RPTN [41, 42], IL4, IL13 [18, 30, 33–35, 40] and its receptors, IFNs [6, 7, 10] and TSLP [13, 14, 18, 30, 40], see Additional file 1 Table S10), we identified CpGs significant by phenotype in the discovery and suggestive in the replication data sets in the IL13 and IL4 genes (Fig. 2, Table 2).