To further investigate the trend whereby ADEH− individuals have methylation values intermediate to healthy controls and ADEH+ individuals but show no statistically significant differences when compared to the ADEH+ patients, we performed an analysis investigating the relationship between different AD severity measures and methylation at the 491 CpGs that were significant (FDR adjusted q-values < 0.05) for at least one pairwise comparison. This evidence concerns the gene ADSS2 and Alzheimer disease.