In order to explore whether PBX1 inhibited HF-MSC apoptosis during HF-iPSC reprogramming through the AKT/GSK3β pathway, HF-MSCs were treated with the specific PI3K/AKT inhibitor LY294002 during HF-iPSC reprogramming induced by SOMKP. The gene discussed is PBX1; the disease is hydrops fetalis.