In addition, compared with HF-MSCs, HF-iPSCs generated by SOMKP transduction (HF-iPSCsSOMKP) exhibited high expression of endogenous FGF4, FOXD3, NANOG, CRIPTO, LIN28, ESG1, endo-OCT4, and endo-SOX2 (P < 0.05, P < 0.001). This evidence concerns the gene CRIPTO and hydrops fetalis.