It also supported the relationship between cancers and proteinuria, and complete removal of the cancer could induce clinical remission of proteinuria [22] We hypothesized that THSD7A might be a tumor antigen released by cancer tissues, the immune system recognized it and produced high-affinity antibodies, which bind to THSD7A on podocyte in situ and formed subepithelial immune complex, then led to proteinuria. The gene discussed is THSD7A; the disease is cancer.