Interestingly, another calcium channel gene, RYR1, which encodes a ryanodine receptor that is present in skeletal muscle and mediates the release of Ca2+ from the sarcoplasmic reticulum into the cytoplasm, also contains mutations that cause porcine malignant hyperthermia susceptibility and pale, soft, and exudative meat [34]. This evidence concerns the gene RYR1 and Malignant hyperthermia.