Pan-PI3K inhibitors wortmannin and LY294002 cause the loss of ICC and the suppression of slow wave in mouse jejunal muscle strips [129]; however, the deletion of c-Kit-induced PI3K signaling (via disruption of PI3K binding to Y719F on c-Kit) was found to have no effect on the function or development of ICC in mice [128]. This evidence concerns the gene PIK3CB and intrahepatic cholangiocarcinoma.