Furthermore, there are promising signs that on-target toxicities can indeed be ameliorated; it has recently been shown that the PI3Kα inhibitor BYL719 (alpelasib/Piqray®) can be administered in a way that minimizes side effects while delivering clinical benefit in patients suffering from overgrowth syndromes driven by somatic PIK3CA mutations [212]. Here, PIK3CA is linked to overgrowth syndrome.