The comparable higher mean age of ALL onset was also observed among children MTHFR 1298 CC-homozygotes (8.03 ± 4.8 years and 7.05 ± 4.8 years, respectively, in the whole cohort and dyads subgroup) while mother MTHFR 1298 stratification did not yield any significant result (Table 2, Table S2). This evidence concerns the gene MTHFR and acute lymphoblastic leukemia.