In details: MTHFR 677 CC-homozygotes (WW/CC 4.8 ± 3.1 years, WD/CC 6.5 ± 4.8 years, and DD/CC 7.3 ± 6.1 years); MTHFR 677 CT-heterozygotes (WW/CT 4.93 ± 4.0 years, WD/CT 6.79 ± 4.1 years, and DD/CT 7.48 ± 4.3 years); MTHFR 677 TT (WW/TT 4.58 ± 2.9 years, WD/TT 5.41 ± 3.2 years, and DD/TT 6.4 ± 3.5 years). The gene discussed is MTHFR; the disease is Wilson disease.