Nutrient-sensing signals are regarded as key players in the developmental programming of hypertension, such as 5’-adenosine monophosphate-activated protein kinase (AMPK), peroxisome proliferator-activated receptor (PPAR), and PPARγ co-activator 1α (PGC-1α) [4,16]. The gene discussed is PRKAA1; the disease is hypertensive disorder.