Preliminary research about how aberrant miRNA expression can influence neuroendocrine cell behaviours showed a direct post-transcriptional repression of NOTCH2 and RBPJ proteins operated by miR-375 (microRNA 375) in Merkel cell carcinoma (MCC), a rare cutaneous neuroendocrine malignancy [100]. The gene discussed is NOTCH2; the disease is Merkel cell skin cancer.