HES1 and neoplasm: However, in MiNEN (mixed neuroendocrine/non neuroendocrine neoplasm), the expression of NOTCH1 and Hes1 is reduced or absent in the neuroendocrine cells, but both NOTCH1 and Hes1 are present in the adenomatous component [84], potentially indicating a possible role of NOTCH as a tumour suppressor gene.