Increasing lines of evidence indicate that nuclear-factor kappaB (NF-κB) and signal transducer and activator of transcription 3 (STAT3) activation can lead to survival, angiogenesis, and metastasis of the cancer cells [43,48,49,50,51,52,53,54,55,56,57,58,59,60,61,62,63,64,65,66,67,68,69,70,71,72,73,74,75,76,77,78]. The gene discussed is STAT3; the disease is cancer.