It has been also reported that Stratifin (SFN) is methylated in 96% of breast cancer patients [107,108], whereas Homeobox A9 (HOXA9) and Engrailed homeobox 1 (EN1) are methylated in 95% and 80% of serum patients with ovarian tumor, respectively [109]. The gene discussed is EN1; the disease is breast carcinoma.