Our previously published data showed that miRNA-5196, miRNA-29a, and miRNA-135b targeting profibrotic Fos-related antigen 2 (Fra2), Tissue inhibitor matrix metalloproteinase-1 (TIMP-1), and Signal transducer and activator of transcription 6 (STAT6), respectively, were able to reverse the profibrotic properties of SSc fibroblasts [21,78,79]. This evidence concerns the gene STAT6 and systemic sclerosis.