We have also shown that specific histones modification induced by histone methyltransferase inhibitor 3-Deazaneplanocin A (DZNep), but not by apicidine (histone deacetylase inhibitor) can induce strong TIMP-1 production in SSc monocytes and promotes pathogenic properties of myofibroblasts [95]. This evidence concerns the gene TIMP1 and systemic sclerosis.