Moreover, some NF1 mutations can lead to the development of the overlapping neurofibromatosis‒Noonan syndrome (MIM #601321) [26,27,28,29,30,31], which combines the typical features of NF1 (CALS, axillary and inguinal freckling, Lisch nodules, OPG, and neurofibromas) and Noonan syndrome (short stature, facial dysmorphism, and congenital heart defects, among others). Here, NF1 is linked to plexiform neurofibroma.