NF1 and neurofibroma: Moreover, some NF1 mutations can lead to the development of the overlapping neurofibromatosis‒Noonan syndrome (MIM #601321) [26,27,28,29,30,31], which combines the typical features of NF1 (CALS, axillary and inguinal freckling, Lisch nodules, OPG, and neurofibromas) and Noonan syndrome (short stature, facial dysmorphism, and congenital heart defects, among others).