In this study, we generated a human GBM cell line transduced with the mutant IDH1 gene (IDH1-mutant U87), evaluated the difference in sensitivity to currently available chemotherapy for GBM (TMZ and Bev) between the IDH1-mutant and IDH1-wildtype types, and investigated the underlying mechanism with a high-precision comprehensive analysis using RNA-seq. This evidence concerns the gene IDH1 and glioblastoma.