To substantiate this, high expression of macrophage inhibitory cytokine 1 (MIC1) has been found in obese patients with PCa [85]; a high-fat diet stimulates several C-X-C motif ligands, and in particular CXCL1, which promotes the recruitment of adipose stromal cells (ASC) from white adipose tissue (WAT) to the tumor, finally inducing tumor growth [86]; a very fat diet may also induce increased leptin level, a hormone hypothesized to support cancer cell proliferation [87]. Here, CXCL1 is linked to neoplasm.