Another study also demonstrated a positive correlation between circulating levels of this adipokine and TNF-α levels in blood from RA patients [161], whereas no relationship with TNF-α, CRP levels, leukocytes counts, or with other pro-inflammatory cytokines such as IL6, IL8, or MCP-1 was found by other authors [128,155]. The gene discussed is TNF; the disease is rheumatoid arthritis.