In fact, when it has been studied whether there is an relationship between synovial and serum levels of adipokines with the development of arthritis in autoantibody-positive individuals at risk of RA, only a significant association between serum levels of vaspin and the disease development was found [241], thus evidencing the complexity of assessing their potential as diagnostic biomarkers. The gene discussed is SERPINA12; the disease is arthritic joint disease.