It promotes the degradation of certain host proteins including alpha thalassemia/mental retardation syndrome X-linked (ATRX) [7], myeloid differentiation factor (MyD88), MyD88 adaptor–like protein (Mal), and Toll-interleukin 1 receptor (TIR) domain–containing adaptor protein (TIRAP) [8], P65 [9], IFI16 [10,11,12], and STING [13] to enhance viral infection and replication by abrogating type I IFN production and facilitating immune evasion [14]. The gene discussed is IFI16; the disease is viral infectious disease.