TIMP1 and non-small cell lung carcinoma: The results reconfirmed that genetically silencing the TIMP-1 gene significantly down-regulated IL-6 mRNA transcription in both NSCLC cell lines, whereas the knockdown of IL-6 did not change TIMP-1 transcription in H460, and caused only limited downregulation in TIMP-1 transcripts in A549 cells (Figure 3G,H).