NFKB1 and neoplasm: OC cells secrete immunosuppressive cytokines to promote pro-tumor phenotypes in tumor-associated macrophages (TAMs), which in turn, secrete immunoinhibitory cytokines such as IL-10 and contribute to constitutive NF-κB activation in OC cells by secreting TNFα, promoting survival, CSC expansion and metastasis [59,60].