Irisin also inhibited the growth, migration, and invasion of MIA PaCa-2 and Panc03.27 pancreatic cancer cells cultured in vitro via the AMPK-mTOR pathway signaling, by increased phosphorylation of AMP-activated protein kinase (AMPKα) and reduction of mammalian target of rapamycin (mTOR) phosphorylation [90]. Here, MTOR is linked to familial pancreatic carcinoma.