ABCA1 and metabolic syndrome: Although somehow contrasting with data published in primary and secondary prevention settings [1,2,3], these results are in line with previous observations in metabolic syndrome and rheumatoid arthritis [4,5,6], and lend weight to the notion that depending on disease-related systemic factors, the associations between macrophage ABCA1-CEC and coronary atherosclerosis burden are not necessarily straightforward.