MKI67 and neoplasm: Notably, there were no significant relationships between response to therapy and characteristics of patients and disease, including age (≤65 vs. >65 years), sex (male vs. female), PS ECOG (1 vs. 2), site of primary tumor [gastro-intestinal (GI) vs. no-GI], KI-67 level (<20 vs. ≥20%), grading (G2 vs. G3), number of metastatic sites (1 vs. 2 vs. ≥3) and previous treatments (see Table S2 in Supplementary Material).