DNM1L and myocardial infarction: A number of experimental studies have demonstrated that mitochondria undergo Drp-1-mediated fission to generate fragmented mitochondria during acute myocardial IR, resulting in mitochondrial dysfunction and cardiomyocyte death, and genetic or pharmacological inhibition of mitochondrial fission in this setting have been reported to reduce MI size in rodent AMI models [32,33,34,35,36,37,38,39,40,41,42,43,44,45,46].