In an earlier study, we demonstrated that mitochondria undergo fission in response to acute myocardial IRI and that pre-treatment with mdivi-1, a small molecule inhibitor of Drp1, inhibited mitochondrial fission and reduced cell death in adult murine cardiomyocytes subjected to simulated IRI, and reduced MI size in an in vivo murine AMI model [32]. The gene discussed is DNM1L; the disease is myocardial infarction.