On the contrary, the proteins HSP90AA1, HSPE1 and ERP29 are mainly functional as molecular chaperone complexes essential for the maintenance of the protein folding and protein trafficking, (see Table 2 and File S3) during cellular stress responses and are a hallmark for various neurodegenerative diseases, including glaucoma [73,74,75]. Here, HSPE1 is linked to neurodegenerative disease.