TERF1 and Infertility: MAJIN mediates inner nuclear membrane attachment through a transmembrane helix, while TERB2 binds to TERB1, which interacts with shelterin component TRF1 to recruit telomeric DNA, and is also thought to bind to the LINC complex.25, 26, 27 Previous genetic studies in mice demonstrated that individual disruption of MAJIN, TERB1, or TERB2 leads to impaired telomere attachment, failure of chromosome movements and infertility.25, 26, 27, 28 We thus initiated structural studies to understand the molecular basis of this essential process of mammalian meiosis.