It has been reported that the activation of Nrf2 prevents the expression of proinflammatory cytokines, including IL-1β, IL-6, and IL-17, in lipopolysaccharide (LPS)-induced macrophages [20], dextran sodium sulfate (DSS)-induced murine colitis [21], and experimentally induced autoimmune encephalomyelitis in mice [22]. Here, NFE2L2 is linked to colitis.