Target genes of the miRNAs that were altered by JM6 (e.g., Creb, Bdnf in Fig 3C) were found to be expressed in limbic brain areas (e.g. hippocampus) in previous studies [43, 44], and involved in the pathophysiology of depression and the response to antidepressants. The gene discussed is CREB1; the disease is depressive symptom measurement.