CFL1 and neoplasm: Here, the new biomarkers that were found in Rho GTPase signaling included phosphorylations of CFL1 at residue S3 (fold change = 0.29, p = 8.00E-05), MYH10 at residue S1975 (fold change = 0.82, p = 3.80E-01), MYH10 at residue S1956 (fold change = 0.80, p = 3.68E-01), MYH10 at residues S1975 and S1956 (fold change = 1.77, p = 3.99E-02), MYH9 at residue S1943 (fold change = 1.40, p = 7.70E-03), and CTNNA1 at residue S518 (fold change = 0.78, p = 1.00E-04), which might be novel molecules and regulation mechanism for tumor invasion and metastasis.