C4A and AIDS: Enhanced HIV/acquired immunodeficiency syndrome (AIDS) susceptibility is visible in individual who has CCL3L1 copy number aberrations [7]; CNV of human Fcgr3 gene is a determinant of glomerulonephritis [8]; Low copy number of component C4 is a danger factor and high copy number is a shielding factor in systemic lupus erythematosus (SLE) [9].