Our study established novel regulatory factors in CRC, and lncRNAs (CASC11, HM13-AS1, ABALON, NKILA, FAM87A, LOC101927752, KBTBD11-OT1, LOC100287015, LOC101929066) were acting as new candidates for CRC diagnosis. The gene discussed is KBTBD11; the disease is colorectal carcinoma.