Given that early‐life wheeze in the absence of other allergic symptoms (such as eczema) is mostly virus‐induced, our results are in agreement with observations from recent studies which provided evidence that polymorphisms on chromosome 17q21 regulate ICAM1 expression and thus may affect the frequency and severity of rhinovirus infection and early childhood wheezing illness,28 that impaired anti‐virus immunity is associated with early‐life wheezing,29 and that early‐life antibiotic use (a proxy for impaired innate anti‐virus immunity) is associated with 17q21 polymorphisms.30 Here, ICAM1 is linked to Eczematoid dermatitis.