Scalco et al reported earlier that hypertension was associated with depression.[43] Conversely, a meta-analysis of prospective cohort studies found no evidence that hypertension would be a risk factor for depression.[44] Recently, the RAAS was proposed as being implicated in depression.[45] There is increasing evidence (largely from animal models) for antidepressant and antianxiety effects of drugs targeting the RAAS.[46–49] Our data provide evidence that depression level after 3-month-long ACE inhibition decreases significantly in patients with newly diagnosed hypertension. The gene discussed is ACE; the disease is major depressive disorder.