CCL2 and gestational diabetes: CCL2/CCR2 mediates glial cell-neuron interaction in central sensitization and chronic pain regulation during the neuroinflammatory response of peripheral nerves after surgical injury.[11] Teler et al[12] research shows that CCL2 rs4586 gene polymorphism is associated with Gestational diabetes mellitus (GDM), the mechanism may be that the polymorphism of this locus affects the expression of CCL2 protein.