CCL2/CCR2 mediates glial cell-neuron interaction in central sensitization and chronic pain regulation during the neuroinflammatory response of peripheral nerves after surgical injury.[11] Teler et al[12] research shows that CCL2 rs4586 gene polymorphism is associated with Gestational diabetes mellitus (GDM), the mechanism may be that the polymorphism of this locus affects the expression of CCL2 protein. Here, CCR2 is linked to gestational diabetes.