EIF2AK2 and Wolcott-Rallison syndrome: WRS is caused by inactivating mutation in the eukaryotic translation initiation factor 2‐alpha kinase 3 (EIF2AK3) gene, also called protein kinase R (PKR)‐like endoplasmic reticulum kinase (PERK), a highly expressed protein in pancreatic islets (Shi et al., 1999).