On the other side, proteasome inhibitors interfere with the NF‐κB pathway because they inhibit IκB degradation, which in turn prevents NF‐κB activation.85 Accordingly, an increased Fbxo32/Atrogin1 gene expression86 and protein ubiquitination86 was associated with an activated UPS in a rat model of cachexia, induced by the Yoshida ascites hepatoma cells. The gene discussed is FBXO32; the disease is Cachexia.