Among the best studied inflammatory cytokines promoting cancer cachexia are TNF, IL6,77 IL1, and interferon gamma,78 which are all elevated79 and may together trigger muscle wasting by increasing NF‐κB activity.80, 81, 82 For instance, TNF promotes anorexia83 and skeletal muscle wasting mainly through activation of the NF‐κB pathway.84 However, the precise mechanism how NF‐κB mediates muscle wasting in cancer is less well understood. The gene discussed is NFKB1; the disease is cancer.