RELA and Sepsis: Of note, NF‐κB p65 was shown to mediate denervation and tumour‐induced muscle atrophy,52, 53 and its inhibition prevented atrophy in a mouse model of acute lung injury.54 Our data corroborate and extend these findings (i) by demonstrating that NF‐κB has an important role in sepsis‐induced atrophy as well and (ii) by identifying SAA1 as a facilitator of the NF‐κB p65 pathway, which mediates most of its effects on myocytes in vitro.