The Homeobox a5 (Hoxa5) gene is an important developmental transcription factor that is highly expressed in adipose tissue.23 Previous studies reported that lung inflammation was observed in Hox5 mutant mice, suggesting that Hoxa5 is involved in vascular inflammation.24, 25 In addition, we previously confirmed that Hoxa5 promotes white adipose tissue browning by inhibiting lipopolysaccharide (LPS)‐induced inflammation in mice.26 However, the regulatory effect of Hoxa5 on obesity‐induced chronic inflammation remains unclear. This evidence concerns the gene HOXA5 and obesity due to melanocortin 4 receptor deficiency.