Analysis of tumor features from 379 patients revealed that high levels of TRPM4 protein were related to aggressive tumor features, including high numbers of tumor buds—which is a sign of EMT, metastasis, and more aggressive infiltrative growth patterns in CRC (Fig. 1) (Georges et al., 2018; Karamitopoulou et al., 2015; Koelzer et al., 2016). This evidence concerns the gene TRPM4 and colorectal carcinoma.