Notably, APC dysfunction (e.g., nuclear translocation of β‐catenin) and SNAIL1 expression have also been discussed in the context of tumor budding, as β‐catenin, SNAIL1, and MMP expression levels are elevated in tumor buds (Galván et al., 2015; Jass et al., 2003; Zlobec and Lugli, 2010). This evidence concerns the gene APC and neoplasm.