Interestingly, mutations in generic structural ER proteins such as atlastin‐1, reticulon‐2, REEP1, and REEP2 are causative for the axonopathy HSP (Hazan et al, 1999; Zhao et al, 2001; Nishimura et al, 2004; Zuchner et al, 2006; Montenegro et al, 2012; Esteves et al, 2014; Yalcin et al, 2017). Here, ATL1 is linked to hereditary spastic paraplegia.