More specifically, dysfunction of ER‐shaping proteins such as atlastin‐1, reticulon‐2, receptor expression‐enhancing protein 1 (REEP1), and receptor expression‐enhancing protein 2 (REEP2) leads to hereditary spastic paraplegia (HSP), whereas mutations in ER receptor VAMP‐associated protein B (VAPB) cause amyotrophic lateral sclerosis (ALS; Hazan et al, 1999; Zhao et al, 2001; Nishimura et al, 2004; Zuchner et al, 2006; Montenegro et al, 2012; Esteves et al, 2014; Yalcin et al, 2017). Here, REEP1 is linked to amyotrophic lateral sclerosis.