PFKFB3 and neoplasm: In tumor cells, cardiomyocytes and macrophages/monocytes, AMPK activation boosts the glycolysis rate by increasing glucose uptake and through by phosphorylation and activation of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2/3, which produces fructose-2,6-bisphosphate, an allosteric activator of glycolytic enzyme phosphofructokinase-1 [228, 229].