For example, ELAVL1 promotes the stability and translation of COX-2 mRNA by binding to its ARE sequences located within the 3′UTR in an advanced tumor stage of CRC tissues (Fan and Steitz, 1998; Dixon et al., 2001; Denkert et al., 2006; Badawi et al., 2017). This evidence concerns the gene PTGS2 and neoplasm.