PTGS2 and cancer: TTP also regulates the expression of cancer-related proteins (Fos, Myc, COX-2, cIAP2, E2F1, Bcl-2, Mcl-1, LATS2, Lin28, and Cyclin D1), which contribute to inflammation, apoptosis, and angiogenesis in CRC (Lee et al., 2010, 2018; Sobolewski et al., 2015).