Also named RBM35A, epithelial splicing regulatory protein 1 (ESRP1) contains three putative RRMs, which are mutational hotspots of primary colon tumors with microsatellite instability (MSI) causing rapid degradation of the mutated transcripts (Leontieva and Ionov, 2009; Deloria et al., 2016; Mager et al., 2017). The gene discussed is ESRP1; the disease is colonic neoplasm.