Based on these observations, congenital heart defects, dysmorphic facial features and intellectual development disorder (CHDFIDD) have been recognized as novel syndrome caused by de novo variants of CDK13 gene (Sifrim et al., 2016; Bostwick et al., 2017; Carneiro et al., 2018; van den Akker et al., 2018). Here, CDK13 is linked to congenital heart defects, dysmorphic facial features, and intellectual developmental disorder.