Additional mutations within the CDK13 gene were recognized in humans resembling at clinical level many symptoms previously associated with loss of function of CDK13 or newly described symptoms, such as autism spectrum disorder, seizures, feeding difficulties and craniofacial dysmorphism including short upslanting palpebral fissures, hypertelorism or telecanthus, medial epicathic folds, low-set, posteriorly rotated ears and small mouth with thin upper lip vermilion (Hamilton et al., 2018). This evidence concerns the gene CDK13 and autism spectrum disorder.