Moreover, RIPK3 knockout protects cIAP2-deficient mice from lethal IAV H1N1 infection via maintenance of pulmonary tissue homeostasis and mice from influenza H7N9 infection via inhibition of host inflammatory response, respectively (Rodrigue-Gervais et al., 2014; Xu et al., 2017). The gene discussed is RIPK3; the disease is influenza.