Recent studies in murine models have identified a protein called Z-DNA/RNA binding protein 1 (ZBP1; also known as DAI/DLM-1) as a key mediator of IAV-induced programmed cell death including apoptosis, necroptosis, and pyroptosis through its interaction with RIPK3, thus controlling the progression of influenza and animal survival (Kuriakose et al., 2016; Thapa et al., 2016; Kesavardhana et al., 2017; Kuriakose and Kanneganti, 2018). The gene discussed is ZBP1; the disease is influenza.