After adjustment with age and gender, we observed that T stage (aHR, 2.1; 95% CI, 1.4–3.0; P = 0.0001), N stage (aHR, 3.1; 95% CI, 2.1–4.6; P < 0.0001), AJCC tumor stage (aHR, 2.7; 95% CI, 1.7–4.3; P < 0.0001), Tumor differentiation (aHR, 2.9; 95% CI, 1.4–6.1; P = 0.0037) and UNC13C expression (aHR, 0.59; 95% CI, 0.35–0.95; P = 0.037) were independent prognostic factors for OSCC. Here, UNC13C is linked to neoplasm.