PML and brain neoplasm: Although JCPyV is episomal in cases of PML, allowing for the presence of all genomic regions of the virus and for the production of viral capsids during the late phase of infection, is not clear where the presence of viral DNA is episomal or integrated in brain tumors, although evidence suggest integration into the cellular DNA, and in these cases, T-Antigen can be expressed without capsid production or viral particle formation.