Furthermore, we note that the lower Lp-PLA2/SOD levels in the severe WMH CSVD patients (Fazekas 3 group) were found compared to those in the mild white matter lesion group (Fazekas 1 group; Fig. 3), stronlgy implying that lower levels of Lp-PLA2/SOD may mediate cognitive impairment in CSVD patients, probably partially via white matter lesion and lacunes. Here, SOD1 is linked to Cognitive impairment.