Adjust for those infective and inflammatory potential confounders, and due to the nature and changes in circulating Lp-PLA2 in CSVD patients, our findings suggest that peripheral vascular or neuroinflammatory damage may be a key mediating mechanism by which Lp-PLA2 predisposes CSVD patients to cognitive impairment. This evidence concerns the gene PLA2G7 and Cognitive impairment.