Analysis of covariance showed significant differences in Lp-PLA2 and SOD levels among the CSVD groups (SCI, MCI and NC) after adjusting other confounders for sex, age, education, BMI, cholesterol, HDL-C, LDL-C, urea, Cr, UA, hypertension, diabetes, CHD, APOE genotype, and medication use (F=11.82, p<0.001 for Lp-LPA2; F=10.354, p<0.001 for SOD, Table 1). This evidence concerns the gene APOE and diabetes mellitus.