PLA2G7 and Cognitive impairment: In our study, there was evidence of variability in the strong correlation between Lp-PLA2 and cognitive impairment in CSVD patients, which was independent of circulating LDL-C levels (Fig. 4A, B; Table 2), directly indicating that circulating LDL-C levels in CSVD patients with cognitive impairment may not influence or participate in the disease pathogenesis but rather that circulating Lp-PLA2 may influence CSVD patients via regulating vascular and neuroinflammatory mechanisms but not lipid metabolism.