Additionally, SIRT1 indirectly regulates the expression of OCT4 and NANOG, which is normally suppressed by P53, by deacetylating P53 in human embryonic stem cells and cancer stem cells [43, 44], while RSV was reported to reduce the protein level of P53 through inducing its deacetylation in adult stem cells [45]. This evidence concerns the gene POU5F1 and cancer.