Gono T compared the cytokine profiles of the anti-MDA5-ILD and anti-ARS-ILD subsets and showed that IL-8 levels were significantly higher, but the ratio of IL-4 to IFN- γ was lower, in anti-MDA5-ILD than in anti-ARS-ILD. This evidence concerns the gene CXCL8 and Axenfeld-Rieger syndrome.