TGF-β isforms elevation has been found in pulmonary arteries from patients with IPAH[31] and MCT model[32, 33], recent finding revealed BMPR2 and TGF-β signaling pathway complex crosstalk play significant role in PAH pathogenesis[5, 32, 33], TGF-β1 is principal growth factor responsible for organ fibrosis. The gene discussed is TGFB1; the disease is pulmonary arterial hypertension.